In contrast, blunted stress reactivity predicted future increased adiposity and obesity, more depression, anxiety and PTSD symptoms, greater illness frequency, musculoskeletal pain and regulatory T-Cell percentage, poorer cognitive ability, poorer self-reported health and physical disability and lower bone mass.Įxaggerated and blunted SAM system and HPA axis stress reactivity predicted distinct physical and mental health and disease outcomes over time. Exaggerated stress reactivity at baseline predicted an increase in risk factors for cardiovascular disease and decreased telomere length at follow-up. low) stress reactivity of both the SAM system and the HPA axis at baseline were related to health and disease outcomes at follow-up. With regard to the significant findings, both exaggerated (i.e. Overall, one third (32% 83/263) of all reported findings were significant and two thirds (68% 180/263) were null. Forty-seven papers met our criteria including 32,866 participants (range 30 – 4100) with 1- 23 years of follow-up. We identified 1,719 papers through database searching and 1 additional paper through other sources. The outcome was any health or disease outcome at follow-up after ≥ 1 year. The exposure was acute psychological stress reactivity (SAM system or HPA axis) at baseline. Included studies were peer-reviewed, English-language, prospective studies in apparently healthy adults. We searched Medline Complete, PsycINFO, CINAHL Complete and Embase up to. ![]() We examined prospective studies in apparently healthy adults to test the hypothesis that the magnitude of the response to acute psychological stress in healthy adults is related to future health and disease outcomes. The relevance of this stress reactivity to long-term health and disease outcomes is of great importance. and Clow, A.Īcute psychological stress activates the sympatho-adrenal medullary (SAM) system and hypothalamo-pituitary adrenal (HPA) axis. Turner, A.I., Smyth, N., Hall, S.J., Torres, S.J., Hussein, M., Jayasinghe, S.U., Ball, K. Psychological stress reactivity and future health and disease outcomes: A systematic review of prospective evidence
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